GSK 3Β INHIBITOR VIII
AR-A014418
CAS: 487021-52-3
Molecular Formula: C12H12N4O4S
GSK 3Β INHIBITOR VIII - Names and Identifiers
| Name | AR-A014418 |
| Synonyms | CS-1021 AR 014418 AR 014418 AR 0133418 AR-A014418 AR-AO 14418 AR-A 014418 AR 0133418 AR-A014418-D3 GSK 3Β INHIBITOR GSK 3Β INHIBITOR VIII AR-A014418(GSK3β Inhibitor VIII) N-(4-Methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea AR 0133418 |
| CAS | 487021-52-3 |
GSK 3Β INHIBITOR VIII - Physico-chemical Properties
| Molecular Formula | C12H12N4O4S |
| Molar Mass | 308.31 |
| Melting Point | 208-210?C (dec.) |
| Solubility | DMSO: ≥20 mg/mL, clear, light yellow H2O: insoluble |
| Appearance | Yellow solid |
| Color | off-white to tan |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| Sensitive | Light Sensitive |
| MDL | MFCD08277040 |
| In vitro study | In 3T3 fibroblasts, AR-A014418 inhibited phosphorylation of tau protein at the specific site of GSK3 (serine 396) with an IC50 of 2.7 μm, in turn, N2A cells are protected from death caused by inhibition of the PI3K/PKB signaling pathway. In hippocampal slices, AR-A014418 inhibited neurodegeneration induced by β-amyloid peptide. In NGP cells and SH-5Y-SY cells, AR-A014418 inhibited neuroendocrine markers and inhibited the growth of neuroma cells. AR-A014418 inhibition of tau phosphorylation at a specific site (serine 396) of GSK3 in 3T3 fibroblasts with an IC50 of 2.7 μm, in turn, N2A cells are protected from death caused by inhibition of the PI3K/PKB signaling pathway. In hippocampal slices, AR-A014418 inhibited neurodegeneration induced by β-amyloid peptide. In NGP cells and SH-5Y-SY cells, AR-A014418 inhibited neuroendocrine markers and inhibited the growth of neuroma cells. |
| In vivo study | In a mouse model of SOD1 protein G93A mutant amyotrophic lateral sclerosis, AR-A014418 (0-4 mg/kg, I. p.) can prolong the occurrence of symptoms, increase muscle vitality, slow down the occurrence of the disease. In addition, AR-A014418 exerts an inhibitory effect on acetic acid and formaldehyde-induced nociception in mice by modulating NMDA and metabotropic receptor signaling pathways and release of TNF-α and IL-1β in the spinal cord. In a mouse model of SOD1 protein G93A mutant amyotrophic lateral sclerosis, AR-A014418 (0-4 mg/kg, I. p.) can prolong the occurrence of symptoms, increase muscle vitality, slow down the occurrence of the disease. In addition, AR-A014418 exerts an inhibitory effect on acetic acid and formaldehyde-induced nociception in mice by modulating NMDA and metabotropic receptor signaling pathways and release of TNF-α and IL-1β in the spinal cord. |
GSK 3Β INHIBITOR VIII - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/39 - |
| WGK Germany | 3 |
GSK 3Β INHIBITOR VIII - Introduction
AR-A014418
Last Update：2022-10-16 17:41:09
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Tel: +16314854226
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Product Name: AR-A014418 Visit Supplier Webpage Request for quotationCAS: 487021-52-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
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View History
GSK 3Β INHIBITOR VIII
(VAL438)-TYROSINASE (432-444) (HUMAN)
PETUNIDIN 3-GLUCOSIDE
山柰酚-3-葡萄糖鼠李糖苷
Acid yellow 127 (C.I. 18888)
AMINOMETHYL PHOSPHONIC ACID-FMOC
1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-[4-(P-MALEIMIDOPHENYL)BUTYRAMIDE] (SODIUM SALT)
PENTAMETHYLCYCLOPENTADIENYLRHODIUM(III) CHLORIDE DIMER
4-苄氧基-3-甲基苯硼酸 (含不同量的酸酐)
D-1-CBZ-NIPECOTIC ACID
(VAL438)-TYROSINASE (432-444) (HUMAN)
PETUNIDIN 3-GLUCOSIDE
山柰酚-3-葡萄糖鼠李糖苷
Acid yellow 127 (C.I. 18888)
AMINOMETHYL PHOSPHONIC ACID-FMOC
1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-[4-(P-MALEIMIDOPHENYL)BUTYRAMIDE] (SODIUM SALT)
PENTAMETHYLCYCLOPENTADIENYLRHODIUM(III) CHLORIDE DIMER
4-苄氧基-3-甲基苯硼酸 (含不同量的酸酐)
D-1-CBZ-NIPECOTIC ACID